The Osprey Mutant 22 is generally designed for climbing, so it's durable and compact. For minimalist travel, it should work well, especially if you're strategic with packing techniques like rolling clothes or using compression bags. Just keep in mind, its 22L capacity means you'll need to be very selective with what you bring, focusing on essentials and versatile clothing. It could definitely help you avoid checked baggage fees, but be prepared for its limited space!